In 2002, Suparna Gupta founded Aangan, with the commitment to protect the most excluded, isolated and vulnerable groups of children. In 2006, she developed a unique model to partner with the state governments across the country, making Aangan the first non-profit to access hundreds of state-run institutional facilities across India for children who were rescued, trafficked and were vulnerable.

In 2009, Suparna extended the organisation's work to identify children in dangerous situations with a view to prevent occurrence and recurrence of serious harm to children. By 2014, this was developed into an integrated model for child harm prevention and is currently implemented in 39 locations across the country.

She has co-authored reports (Changing Spaces in 2006, See You Again if I Survive in 2007, A Real Opportunity for Change in 2010) and led the development of training and empowerment tools for parent, caregivers and children.